Diyabetes nıellir us, koroner arter hastalığr aortik disfonksiyon için önemli bir risk oluşturnraktadtr. Çalışmamızın amacı, diyabetik olan koroner arter hastalarmda aortan111 e/astik özelliklerindeki değişiklikleri göstermek ve buna gliserol Irinitra/m (GT) etkisini araştmııaktrr . Metod: Bu amaçla çalrşmaya diyabet i ve koroner arter hastaltğr olan 17 olgu (13 kadur, 4 erkek, yaş ortalamasr 58.4±9.4 yri) çaltşma grubu (ÇG) olarak ve koroner arter lıastaltğr o/an.jakat diyabeti olmayan 20 olgu (14 kadm, 6 erkek, yaş ortalamost 56.0±10.7 yri) kontrol grubu (KG) olarak altndr. Hastalara transtorasik ekokardiyografi yaptldr. İntravenöz yol ile 200 pg GT öncesi ve sonrasmda, aortik sistolik ve eliyasto/ik çap indeksleri ve aorrik "distensibilite" ve "stiffiıess" indeks ölçüldü. Bulgular: Her iki grupta GT öncesi yaption karştlaşttrnıada yaş, cinsiyet, sigara ku/lamnıt stkltğt, sisto/ik ve eliyasto/ik tansiyon ortalamalan, aortik sisro/ik ve di yasto/ik çaplan indeksleri baktnundan anlamlt farklt/tk yokttı. Çaltşma grubunda KG'ye göre aortik "distensibilite" daha düşiik (s rrasryla 0.0015± 0.0005 ve 0.0026± 0.0007 nımHg·l, pAnahtar Kelimeler: Aortik "distensibilite" ve "stiffness" indeks, diyabetes mellitus

Diabetes mellitus is a major risk factor for coronary artery disease and aortic dysfunction. The aim of this study was to determine the changes in the aortic elastic properties in patients (pts) with diabetic coronary artery disease and to search the effect glycerol trinitrate (GT). Method: Patients with coronary artery disease were allocated into two groups. Study group (SG) consisted of 17 pts ( 13 women 4 men; mean age 58.4±9.4 years) with diabetes mellitus, and the control group (CG) 20 pts (14 women, mean age 56.0±10.7 years) without diabetes mellitus. Aortic systolic and di astolic dameter indexes and aortic distensibility and stiffness index were measured before and after 200 pg GT (i ntravenously) by transthorasic echocardiography. Results: There were no statistically significant differences between the two groups before GT with regard to age, sex, smoking, systolic and diastolic blood pressures, aortic systolic and diastolic diameter indexes. Aortic distensibility was found to be lower and stiffness index was found to be higher in SG (for the distensibility 0.0015± 0.0005 vs 0.0026±0.0007 mmHg-1, pKeywords: Aortic distensibility and stiffness index, diabetes mellitus