Amaç: Sağlıklı bireylerle yavaş koroner akmılı hastalar aras111da endotelin-i (ET-1) düzeylerinin karşı/aştmlması ve ET-1 ile düzeltilmiş TIM/ kare say/SI (cTFC) ilişkisinin araştıni ması. Yöntem: 31 yavaş koroner aktmli hasta (grup A) ve 15 sağlıkli kişide (grup B) istirahat ET-i düzeyleri gruplar arasmda karşılaştmldı. Aym zamanda düzeltilmiş TIM/ kare sayıst ile ET-i arasındaki ilişki araştmldt. Bulgular: İstirahat ET-i düzeyleri yavaş koroner akınıli hastalarda (grup A) sağlik/ı bireylerle (grup B) karş tlaş tı n ldtğında anlamlı derecede yüksek bulundu. (4.348±1 .3 pg/ml-2.524±0.5 pg/m/, p0.05). Damar saylSina göre hastalar sımf/andın ldt ğmda 3 koroner arterinde yavaş koroner akmı olan hastalarda ET-1 düzeyleri en yüksek olarak saptandi. (3 damar; 5.779±1 .2 pg/ml, 2 damar; 4.227±1 .16 pg/ml, 1 damar; 3.411±0.7 pg/ml. pAnahtar Kelimeler: Yavaş koroner akım, endotelin-I, düzeltilmiş TIMI kare sayısı

Purpose: The aim of this study is to compaı·e the enclothelin levels between patients with slow coronary flow and normal healthy subjects, anel to investigate the relationship between endothelin-1 levels (ET -1 ) and correctecl TIMI frame co u nt (cTFC) between the two groups. Method: The resting ET- ı levels w ere compareel be tween two groups (in 31 pa tients with s low coronary flow (groupA) and 15 heaıthy subjects (group B). At the same time the relationship between ET -1 and cTFC w as al so investigated. Results: Resting ET-I levels were found significantly high in patients with slow coronary flow when compareel with healthy subj ects (4,35±1.3 pg/ml vs 2.52±0.5 pg/ml, p<0.01). When the coronary vessels were compareel with each other according to the TIMI frame co u nt and ET- ı levels, if the dominant slow coronary flow was especially LAD arte ry (cTFC highest), ET-1 levels were found higher in these patients than in the ones with dominant Cx (p<0.02) or right corona ry artery (p<0.03). (LAD; 5.826±0,75 pg/ml , Cx; 4, 12±1.17 pg/ml, RCA; 3.89±1.49 pg/ml). But if slow coronary flow was dominant in Cx or RCA artery, not signif icant relationship between cTFC and ET-I levels was detected. When patients were classified according to the number of the diseased vessels, ET-1 levels were found highest in patients with 3-vessel d isease (3- vessel; 5,78±1,2 pg/ml, 2-vessel; 4.23±1.16 pg/ml, single vessel; 3.41±0,7 pg/ml. pKeywords: Slow coronary artery flow, endothelin- I, corrected TIMI frame count.