Turk J Pharm Sci. Ahead of Print: TJPS-96020 | |||
Efficacy of ABCA1 Transporter Proteins in Endometrial CancerŞerife Efsun Antmen1, Cem Yalaza2, Necmiye Canacankatan1, Hakan Aytan3, Ferah Tuncel4, Sema Erden Ertürk51Mersin University, Faculty of Pharmacy, Department of Basic Pharmacy, Department of Biochemistry.2Vocational School of Health Services, Toros University, Mersin, Turkey. 3Department of Obstetrics and Gynecology, Faculty of Medicine, Mersin University, Mersin 4Department of Pathology, Faculty of Medicine, Mersin University, Mersin, Turkey. 5Vocational School of Health Services, Mersin University, Mersin, Turkey. INTRODUCTION: Endometrial carcinoma is a typical gynecological malignant tumor which is occurring more frequently every year (EC). Obesity is a significant contributor to the development of EC and its prognosis. Lipid metabolism problem and malignant tumors have a long history of association. Elevated cholesterol levels are made possible by adenosine triphosphate binding cassette protein A1 (ABCA1) deficiency, which eventually promotes the survival of cancer cells. The relationship between ABCA1 and the occurrence, progression, and prognosis of EC is discussed in this article, as well as a potential mechanism. Corresponding Author: Şerife Efsun Antmen, Türkiye |
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