Valuing best poloxamer carrier for thiocolchicoside solid dispersions

INTRODUCTION: The present attempt is aimed to discover the best Poloxamer grade as solid dispersion carrier by taking Thiocolchicoside as a model drug.
METHODS: The compatibility of Thiocolchicoside with excipients used was studies by differential scanning calorimetry and Fourier Transform Infra-red Spectroscopy. Different formulations of solid dispersions were prepared by using Poloxamer carriers viz., Poloxamer-108, Poloxamer-188, Poloxamer-237, Poloxamer-338 and Poloxamer-407 were prepared by taking Thiocolchicoside: Poloxamer in the ratios ranged from 1: 1, 1: 2, 1: 4 and 1: 6. The solid dispersions were prepared by a novel microwave fusion method and compressed using 8 station tablet compression machine. The fabricated solid dispersion tablets were evaluated for physicochemical characteristics and dug release rates. The release of Thiocolchicoside from the prepared solid dispersions was further analyzed by kinetic models.
RESULTS: Thiocolchicoside was found to be compatible with the Poloxamer carriers used. The solid dispersion formulations were shown satisfactory physicochemical characteristics and Thiocolchicoside release which follows first order release.
DISCUSSION AND CONCLUSION: Among the Poloxamer carriers used, Poloxamer-188 was found to be the best carrier for increasing the solubility and release rate of Thiocolchicoside form the solid dispersions.