Simultaneous Quantification of Metolazoneand Ramiprilin Their Combined Dosage Form by First Order Derivative Spectroscopic Method
Chhalotiya Usmangani K.Department Of Pharmaceutical Chemistry And Analysis, Indukaka Ipcowala College Of Pharmacy, Beyond Gidc, P.b. No. 53, Vitthal Udyognagar- 388 121,gujarat, IndiaA simple, accurate and precise first order derivative spectrophotometric method was developed for simultaneous determination of Metolazone (MET) and Ramipril (RAM) in their combined pharmaceutical dosage form. MET and RAM were quantified using first derivative responses at 285nm and 212nm respectively. Methanol was taken as a common solvent. The calibration curve were linear in the concentration range of 5-25 µg/mL for MET and 8-24 µg/mL for RAM. The method was validated and found to be accurate and precise. Developed method was successfully applied for the estimation of MET and RAM in their combined dosage form
Keywords: Metolazone (MET), Ramipril (RAM), first order derivative, ValidationSimultaneous Quantification of Metolazoneand Ramiprilin Their Combined Dosage Form by First Order Derivative Spectroscopic Method
Chhalotiya Usmangani K.Department Of Pharmaceutical Chemistry And Analysis, Indukaka Ipcowala College Of Pharmacy, Beyond Gidc, P.b. No. 53, Vitthal Udyognagar- 388 121,gujarat, IndiaA simple, accurate and precise first order derivative spectrophotometric method was developed for simultaneous determination of Metolazone (MET) and Ramipril (RAM) in their combined pharmaceutical dosage form. MET and RAM were quantified using first derivative responses at 285nm and 212nm respectively. Methanol was taken as a common solvent. The calibration curve were linear in the concentration range of 5-25 µg/mL for MET and 8-24 µg/mL for RAM. The method was validated and found to be accurate and precise. Developed method was successfully applied for the estimation of MET and RAM in their combined dosage form
Anahtar Kelimeler: Metolazone (MET), Ramipril (RAM), first order derivative, ValidationCorresponding Author: Chhalotiya Usmangani K., India
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