Investigation of the Antimicrobial Activity of Some Ethyl Paraben Hydrazide-Hydrazone Derivatives

INTRODUCTION: The development of antimicrobial molecules that have been discussed with big achievement over the past decades provided many classes of semisynthetic or synthetic compounds. The resistance to many antimicrobial agents requires the discovery of novel molecules.
METHODS: In this study, ten previously reported ethyl paraben hydrazide-hydrazone derivatives were evaluated for their in vitro antibacterial and antifungal activities. The microbroth dilution method was used for the determination of the minimum inhibitory concentration (MIC) values of novel molecules.
RESULTS: The antimicrobial activities of the molecules were found in a wide range with MIC values of 2-256 μg/mL. The synthesized compounds showed good to moderate antimicrobial activity compared with the standards. Among the synthesized molecules, Compound 3g showed the best antimicrobial activity at 2 (μg/mL) to Staphylococcus aureus strain (ATCC 29213).
DISCUSSION AND CONCLUSION: Ethyl Paraben hydrazide-hydrazone compounds in our study were found to have antimicrobial activities. Ethyl paraben is currently used as an antibacterial agent and preservative in preparations. These studies are necessary since they detect the relationship between the substitutions and activity.