The Cardiopulmonary Effects of Calcitonin-Gene Related Peptide Family
GOKÇEN TELLI1, BANU CAHIDE TEL1, BÜLENT GÜMÜSEL21Hacettepe University Faculty of Pharmacy Department of Pharmacology2Lokman Hekim University Faculty of Pharmacy Department of Pharmacology
The cardiopulmonary diseases are very common in the population. They are high-cost diseases and there are still no definitive treatments. The roles of members of the calcitonin-gene-related peptide (CGRP) family in the cardiopulmonary diseases have been studied for many years and promising results are obtained. Especially in recent years, two important members of the family, adrenomedullin and adrenomedullin2/intermedin, are considered as new treatment targets in cardiopulmonary diseases. In this review, the roles of CGRP family peptides in cardiopulmonary diseases has been investigated according to the studies that were performed to the present day.
Keywords: CGRP family, cardiopulmonary diseases, adrenomedullin, adrenomedullin2/intermedin, pulmonary hypertensionKalsitonin-Geni İle İlişkili Peptit Ailesinin Kardiyopulmoner Etkileri
GOKÇEN TELLI1, BANU CAHIDE TEL1, BÜLENT GÜMÜSEL21Hacettepe Üniversitesi Eczacılık Fakültesi Farmakoloji Anabilim Dalı2Lokman Hekim Üniversitesi Eczacılık Fakültesi Farmakoloji Anabilim Dalı
Kardiyopulmoner hastalıklar toplumda sık görülen, tedavi maliyeti oldukça yüksek ve halen kesin bir tedavisi bulunmayan hastalıklardır. Kalsitonin-geni ile ilişkili peptit ailesinin üyelerinin bir çok kardiyopulmoner hastalıktaki rolleri uzun yıllardır çalışılmakta ve umut vadeden sonuçlar elde edilmektedir. Özellikle son yıllarda CGRP ailesine ait peptitlerden adrenomedullin ve intermedin kardiyopulmoner hastalıklarda yeni tedavi hedefleri olarak değerlendirilmektedir. Bu derleme ile CGRP ailesi peptitlerinin kardiyopulmoner hastalıklardaki roller günümüze kadar yapılan çalışmalar doğrultusunda incelenmiştir.
Anahtar Kelimeler: CGRP ailesi, kardiyopulmoner hastalıklar, adrenomedullin, adrenomedullin2/intermedin, pulmoner hipertansiyonCorresponding Author: BÜLENT GÜMÜSEL, Türkiye
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