Preparation and evaluation ofhollow calcium pectinate beads for floating-pulsatile drug delivery
S. Z. Chemate, G. R. Godge, K. K. Pawa, K. A. RupnarP.d.v.v.p.f’s College Of Pharmacy, Viladghat, Ahmednagar-414111, Maharashtra, India.The purpose of this work was to develop hollow calcium pectinate beads for floating-pulsatile release of ofloxacin intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. A controlled release system designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of floating drug delivery system by rate controlled drug delivery approach. To overcome limitations of various approaches for imparting buoyancy, hollow/porous beads were prepared by simple process of acid-base reaction during ionotropic crosslinking. The floating beads provided expected two-phase release pattern with initial lag time during floating in acidic medium followed by rapid pulse release in phosphate buffer. The floating beads obtained were porous (38% porosity), hollow with bulk density <1 and had Ft50% of 16–22 h. This approach suggested the use of floating pulsatile dosage forms as they have potential for use as controlled-release drug delivery systems for site and time-specific release of drugs acting as per chronotherapy of diseases.
Keywords: Calcium pectinate beads, Chronotherapy, Buoyancy, Floating-pulsatile drug deliveryPreparation and evaluation ofhollow calcium pectinate beads for floating-pulsatile drug delivery
S. Z. Chemate, G. R. Godge, K. K. Pawa, K. A. RupnarP.d.v.v.p.f’s College Of Pharmacy, Viladghat, Ahmednagar-414111, Maharashtra, India.The purpose of this work was to develop hollow calcium pectinate beads for floating-pulsatile release of ofloxacin intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. A controlled release system designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of floating drug delivery system by rate controlled drug delivery approach. To overcome limitations of various approaches for imparting buoyancy, hollow/porous beads were prepared by simple process of acid-base reaction during ionotropic crosslinking. The floating beads provided expected two-phase release pattern with initial lag time during floating in acidic medium followed by rapid pulse release in phosphate buffer. The floating beads obtained were porous (38% porosity), hollow with bulk density <1 and had Ft50% of 16–22 h. This approach suggested the use of floating pulsatile dosage forms as they have potential for use as controlled-release drug delivery systems for site and time-specific release of drugs acting as per chronotherapy of diseases.
Anahtar Kelimeler: Calcium pectinate beads, Chronotherapy, Buoyancy, Floating-pulsatile drug deliveryCorresponding Author: G. R. Godge, India
| TOOLS |
 Full Text PDF Print Download citation RIS EndNote BibTex Medlars Procite Reference Manager Share with email Share Send email to author
Similar articles PubMed Google Scholar |