Synthesis And Biological Screening Of Some Novel Triazole Derivatives

Acar, Ulviye; Abumohsen, Usama; Özkay, Yusuf; Karaca, Hülya; Kaplancıklı, Zafer Asım

Ulviye Acar¹, Usama Abumohsen², Yusuf Özkay¹, Hülya Karaca³, Zafer Asım Kaplancıklı¹

¹Anadolu University, Faculty Of Pharmacy, Depatment Of Pharmaceutical Chemistry, Eskişehir-turkey
²Al-azhar University, Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry, Gaza-palestine
³Anadolu University, Faculty Of Pharmacy, Depatment Of Pharmaceutical Microbiology, Eskişehir-turkey

In the present study 15 novel triazolecompounds were synthesized in order to investigate their anticandidal and anticholinesterase activities. Structures of the synthesized compounds were elucidated by spectral data and elemental analyses. Anticandidalactivity tests were performed against four different fungal strains. Compounds 4j, 4k, and 4l displayed moderateanticandidal activity against Candidaglabrata(ATCC 90030)and Candidaalbicans (ATCC 10231). Anticholinesterase activity of the synthesized compounds against acetylcholinesterase (AChE) was also studied. However synthesized compounds did not indicate important enzyme inhibition

Keywords:

Synthesis And Biological Screening Of Some Novel Triazole Derivatives

Ulviye Acar¹, Usama Abumohsen², Yusuf Özkay¹, Hülya Karaca³, Zafer Asım Kaplancıklı¹

Bu çalışmada antikandidal ve antikolinesteraz aktivitelerini incelemek amacıyla 15 yeni triazol türevi bileşik sentezlenmiştir. Sentezi gerçekleştirilen bileşiklerin yapıları spektral veriler ve elementel analiz sonuçları yardımıyla aydınlatılmıştır. Bileşiklerin antikandidal aktiviteleri dört farklı mantar suşuna karşı test edilmiştir. Bileşik 4j, 4k ve 4lCandida glabrata(ATCC 90030)ve Candida albicans’a (ATCC 10231)karşıorta düzeydeantikandidal aktivite göstermiştir. Sentezlenen bileşiklerin asetilkolinesteraza (AChE) karşı antikolinesteraz aktiviteleri de incelenmiştir. Ancak, bileşiklerin hiçbiri önemli bir enzim inhibisyonugöstermemiştir.

Anahtar Kelimeler:

Ulviye Acar, Usama Abumohsen, Yusuf Özkay, Hülya Karaca, Zafer Asım Kaplancıklı. Synthesis And Biological Screening Of Some Novel Triazole Derivatives. . 2015; 12(2): 25-35

Corresponding Author: Yusuf Özkay, Türkiye