Folate Mediated Paclitaxel Nanodelivery Systems: A Comprehensive Review

Paclitaxel is at present utilized as viable anticancer medication in the chemotherapy of breast, ovarian, lung, bladder, neck, head, esophageal tumors. The focus of this review is to survey various folate-targeting paclitaxel loaded nano preparations in both research and clinical applications. There are diverse nano preparations including liposomes, micelles, polymeric nano preparations, lipid nano preparations, lipoprotein nano carriers, and other inorganic nano preparations for folate associated paclitaxel tumor targeting. Here, the folate targeting paclitaxel loaded nano preparations which have promising results in constructive treatment of cancer by reducing toxic side-effects and/or improving effectiveness were mainly reviewed.