Development and evaluation of in- situ gel formation for treatment of mouth ulcer

INTRODUCTION: Mouth ulcers are one of the most prevalent conditions that can be caused by a range of circumstances. Many formulations, such as solution, suspension, and ointments, are available commercially. However, because there is no long-term effect, no medication can be regarded to be totally effective in the treatment of mouth ulcers. The use of a bio adhesive method can boost the therapy's efficacy. Because it is easier to administer than prepared gel formulations, the phenomena of sol to gel conversion can be beneficial.
The major goal of this study is to develop and test in situ gels for treating mouth ulcers utilizing choline salicylate and borax as model medicines.
METHODS: Because a thermosensitive polymer was employed in this formulation, the Sol-to-gel change was thermally reversible, and the frequency of administration was reduced by using the mucoadhesive polymer Carbopol. Gelation temperature, pH, gel strength, Spreadability, in vitro mucoadhesion, and in vitro drug release were all measured in the formulations.

RESULTS: The experimental section indicated that viscosity of sols and gel strength was increased with increase in temperature, i. e. gel can be created at site of application owing to body temperature. When Poloxamer 407 was used at a concentration of 14 to 16 percent w/v, the gelling temperature was close to the body temperature (35-38°C), but when here Carbopol 934P was added, the gelling temperature was raised. All formulations had a pH between 5.5 and 6.8, All formulations had viscosities of less than 1000 cps, allowing for simple administration of the formulation to a mouth ulcer.
DISCUSSION AND CONCLUSION: As a result, a correctly developed in-situ gel for oral ulcers can extend the duration spent at the application site and minimize the frequency of administration. These findings show that the created technology is a viable alternative to traditional drug delivery systems and can help patients comply.