. Ahead of Print: TJPS-23890 | |||
A Preliminary Study on the Effect of Deferoxamine on Disruption of Bacterial Biofilms and Antimicrobial ResistanceAybala Temel1, Zinnet Şevval AKSOYALP21Izmir Katip Celebi University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Izmir, Türkiye.2Izmir Katip Celebi University, Faculty of Pharmacy, Department of Pharmacology, Izmir, Türkiye. INTRODUCTION: Antivirulence therapy approaches have emerged as remarkable strategies in the fight against antibiotic resistance. Metal ions, particularly iron, play a crucial role in the metabolic activities and virulence of bacteria. Loading iron into siderophore molecules offers a potential avenue to circumvent antimicrobial resistance. This study aimed to evaluate the antibiofilm and antimicrobial effect of deferoxamine (DFO) on antibiotic susceptibility in clinical methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. Corresponding Author: Aybala Temel, Türkiye |
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