Synthesis and Antibacterial Activity of Some Azetidinone Derivatives Containing 2-Amino 6,7 Substituted Benzothiazole

Sarkar, Sibaji; Chauhan, Rajani; Dwivedi, Jaya

Sibaji Sarkar¹, Rajani Chauhan², Jaya Dwivedi³

¹N. R Vekaria Institute Of Pharmacy, C.l College Campus, Junagadh. Gujarat- 362001, Indıa
²Banasthali University, Department Of Pharmacy, Rajasthan - 304022, Indıa
³Banasthali University, Department Of Chemistry, Rajasthan -304022, Indıa

A novel series of azetidinone AZ1-6 been prepared from the building blocks 2, 3, 4 (trisubstituted benzaldehyde)-N-(6,7 substituted-1,3-benzothiazol-2-yl) semicarbazone [2.026a-o]. All of the synthesized compounds have been confirmed by elemental analyses, IR and 1H NMR spectral data. These newly synthesized compounds were screened for their antibacterial activity. Variable and modest activity was observed against the investigated strains of bacteria, however compounds AZ2, AZ3, AZ5 and AZ6 revealed significant antibacterial activity against Bacillus subtilis and Pseudomonas compared to the reference drug Procaine penicillin and Streptomycin.

Keywords:

2-Amino-6,7-Sübstitüe Benzotiyazol İçeren Bazı Azetidinon Türevlerinin Sentezi ve Antibakteriyel Aktiviteleri

Sibaji Sarkar¹, Rajani Chauhan², Jaya Dwivedi³

2, 3, 4 (trisübstitüe benzaldehit)-N-(6, 7 sübstitüe-1,3-benzotiyazol-2-il) semikarbazon [2.026a-o] dan hareketle yeni bir seri azetidinon (AZ1-6) türevi hazırlanmıştır. Sentezlenen bileşiklerin yapıları elemental analiz, IR ve 1H NMR verileriyle kanıtlanmış ve antibakteriyel aktiviteleri denenmiştir. Bileşiklerden AZ2, AZ3, AZ5 ve AZ6 Bacillus subtilis ve Pseudomona’a karşı referans bileşikler Prokain penisilin ve Streptomisin ile kıyaslandıklarında kayda değer aktiviteye sahip bulunmuştur.

Anahtar Kelimeler:

Sibaji Sarkar, Rajani Chauhan, Jaya Dwivedi. Synthesis and Antibacterial Activity of Some Azetidinone Derivatives Containing 2-Amino 6,7 Substituted Benzothiazole. . 2015; 12(1): 0-0

Corresponding Author: Sibaji Sarkar, India