Maternal occupational exposure to asthmogens during pregnancy and risk of asthma in children: a meta-analysis

Background and introduction: The association between occupational exposure during pregnancy and the subsequent development of asthma in their children has always been a matter of debate and the results of cohort studies on this issue have been controversial. The best of our knowledge, this is the first systematic review and meta-analysis that aims to evaluate the risk of developing subsequent asthma in children based on maternal occupational exposure in the gestation period.
Materials and Methods: In order to retrieve eligible studies, an advanced literature search was performed up to August 10,2023 from the following databases: PubMed, Scopus, and Google Scholars. The title and abstract of related articles were screened hence the full texts there reviewed. Data extraction was conducted, hence the included articles where analysis to assess the mention association
Results: From total of 10 cohort studies with a total record of 5372 it was found that there's no significant relationship between maternal occupational exposure to asthmogens during pregnancy and later asthma in children. The pooled odds ratio of asthmatic children in patients with maternal occupational exposure to asthmogens during pregnancy was 1.03 (95% Confidence interval,0.97-1.09) I2= 13% P=0.62
Conclusion It was concluded that there's no significant association between maternal occupational exposure and future asthma in children. However, future large scaled studies are still required to support these results.