. 2005; 2(4): 305-310 | |||
ELEVATED SERUM LEVELS OF HUMAN CHORİONİC GONADOTROPHİN AND ALPA-FETOPROTEİN PREDİCTİNG FOR DEVELOPMENT OF SEVERE PREECLAMPSİAZeynep Genç, Oya Balta, Sadiye Eren, Elif BağlamHospitalOBJECTIVE: Our purpose was to study the correlation between maternal serum total chorionic gonadotrophin (MShCG) levels and maternal serum alpha fetoprotein (MSAFP) levels measured at 15-19 week’s gestation and pre-eclampsia. METHODS: This retrospective study was conducted from May 2002 to October 2003 at Zeynep Kamil Gynecology and Obstetrics Hospital. Thirty two cases with mild pre-eclampcia and thirty two cases with severe pre-eclampsia were recruited as the study groups. 305 normotensive women were enrolled as controls. Measurement of MShCG and MSAFP were made from 15-19 week’s gestation as part of antenatal serum screening for Down’s Syndrome in the second trimester. Serum alpha fetoprotein was measured by radio-immunoassay and serum total human chorionic gonadotrophin was measured by immunoradiometric technique. RESULT: MShCG levels and MSAFP levels were significantly higher in severely pre-eclamptic women (p<0.05), but not in those with mild pre-eclampsia, compared with those in their matched controls. CONCLUSION: Elevated mid trimester serum human chorionic gonadotrophin levels and alpha-fetoprotein levels may help in the prediction of severe pre-eclampsia. High MShCG levels in severely pre-eclamptic women might reflect a significantly pathologic change and secretory reaction of placenta. Keywords: human chorionic gonadotophin, maternal serum alpha-fetoptrotein, pre-eclampsiaSerum Total Koryonik Gonadotropin ve Alfa Feto-Protein Düzeyleri ile Pre-Eklampsi Gelişimi arasındaki ilişkiZeynep Genç, Oya Balta, Sadiye Eren, Elif BağlamHastaneAMAÇ: Gebeliğin 15-19 haftaları arasında bakılan serum total koryonik gonadotropin düzeyleri ve serum alfa feto-protein düzeyleri ile ileride gelişebilecek olan pre-eklampsi arasında ilişki olup olmadığını araştırmak. Materyal ve METHOD: Bu çalışma Mayıs 2002 ve Ekim 2003 tarihleri arasında Zeynep Kamil Kadın Hastalıkları ve Doğum Kliniğine Zeynep Genç, Oya Balta, Sadiye Eren, Elif Bağlam. ELEVATED SERUM LEVELS OF HUMAN CHORİONİC GONADOTROPHİN AND ALPA-FETOPROTEİN PREDİCTİNG FOR DEVELOPMENT OF SEVERE PREECLAMPSİA. . 2005; 2(4): 305-310 Corresponding Author: Oya Balta, Türkiye |
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