18F-FDG PET/CT showing rare mediastinal growing teratoma syndrome following chemotherapy
Mihoko Sasahara1, Takashi Abe2, Yoichi Otomi1, Yumi Abe2, Hiroaki Toba3, Takayoshi Shinya1, Hideki Otsuka1, Masafumi Harada11Department of Radiology, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima Prefecture, 770-8503, Japan2Department of Radiology, Nagoya University Hospital, 65 Tsurumai, Showa-ku, Nagoya City, Aichi Prefecture, 466-8550, Japan
3Department of Thoracic and Endocrine Surgery and Oncology, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima Prefecture, 770-8503, Japan
Growing teratoma syndrome (GTS) is a condition in which poorly differentiated cells in a mixed-germ cell tumor regress after chemotherapy, and the number of well-differentiated components increases. A 60-year-old man was found to have an 8.0-cm mediastinal tumor with strong 18F-FDG uptake (SUVmax = 9.2), which was diagnosed as a germ cell tumor. After chemotherapy, serum alpha fetoprotein, beta-human chorionic gonadotropin, and tumor 18F-FDG uptake decreased (SUVmax = 3.9), but the tumor volume increased. The tumor was completely resected, and pathology confirmed the diagnosis of GTS. 18F-FDG PET after chemotherapy reflects the proliferation of highly differentiated tumor components with poor 18F-FDG uptake.
Keywords: growing teratoma syndrome, 18F-FDG PET, mediastinum, germ cell tumorMihoko Sasahara, Takashi Abe, Yoichi Otomi, Yumi Abe, Hiroaki Toba, Takayoshi Shinya, Hideki Otsuka, Masafumi Harada. 18F-FDG PET/CT showing rare mediastinal growing teratoma syndrome following chemotherapy. . 2022; 31(3): 239-241
Corresponding Author: Mihoko Sasahara, Japan
Corresponding Author: Mihoko Sasahara, Japan
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