Oncological follow-up with 2-[18F]FDG PET/CT in li fraumeni syndrome

Li-Fraumeni syndrome is a rare disorder caused by abnormalities of the tumor suppressor protein P53 gene. We present the case of a female patient 26 years old with diagnosis of bilateral ductal carcinoma. The genetic panel for BRCA1 and BRCA2 mutations was negative and positive heterozygous germline TP53 gene mutations, considering Li-Fraumeni syndrome. A 2-[18F]FDG PET/CT for post-surgical staging showing right lung hypermetabolic nodule. A lobectomy was accomplished and histopathology reported pulmonary adenocarcinoma. A year later, oncological follow-up was indicated with 2- [18F] FDG PET/CT without evidence of abnormalities.