Attention-deficit hyperactivity disorder and gluten sensitivity in childrenCeyda Tuna Kırsaçlıoğlu1, Gulin Hizal1, Gulser Dinc2, Seyhan Temtek Güner2, Semih Sandal1, Özden Üneri21Department Of Pediatric Gastroenterology, Hepatology And Nutrition, Turkish Republic Health Ministry Ankara Child Health Diseases, Haematology Oncology Training And Research Hospital, Ankara, Turkey 2Department Of Child And Adolescent Psychiatry, Turkish Republic Health Ministry Ankara Child Health Diseases, Haematology Oncology Training And Research Hospital, Ankara, Turkey
INTRODUCTION: Dietary factors are considered one of the possible environmental risk factors for attention-deficit hyperactivity disorder (ADHD). The aim of the study was to demonstrate the relationship between ADHD and celiac disease (CD) and non-celiac gluten sensitivity (NCGS) in children. METHODS: In this prospective study, the children with ADHD, aged 6-18 years, were asked for the presence of gastrointestinal symptoms and their relationship with gluten intake with a previously prepared questionnaire form. Also, they were screened for CD (anti-tissue transglutaminase immunoglobulin (Ig) A and total IgA) and NCGS (anti-gliadin IgA/ IgG antibodies). RESULTS: Of the 117 children (76% male), the mean age was 9.2 ± 2.4 years. Ninety-six patients (82%) had no gastrointestinal complaints. There was no relationship between gluten intake and complaints in the patients who had constipation (12.8%), recurrent abdominal pain (2.5%), dyspeptic symptoms (1.7%), and irritable bowel syndrome (0.8%). None of the patients had anti-tissue transglutaminase IgA or IgG positivity. Only 1 (0.8%) patient had anti-gliadin IgA, 6 (5.1%) patients had anti-gliadin IgG positivity. There wasn’t any relation between the presence of symptoms and anti-gliadin IgG positivity (p= 0.08). DISCUSSION AND CONCLUSION: There was no increase in the frequency of CD and NCGS in the children with ADHD
Keywords: Attention-deficit hyperactivity disorder, celiac disease, children, non-celiac gluten sensivity.
Ceyda Tuna Kırsaçlıoğlu, Gulin Hizal, Gulser Dinc, Seyhan Temtek Güner, Semih Sandal, Özden Üneri. Attention-deficit hyperactivity disorder and gluten sensitivity in children. . 2021; 8(3): 326-329
Corresponding Author: Ceyda Tuna Kırsaçlıoğlu, Türkiye |
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