. 2022; 9(1): 60-65 | |||
Thiopurine-S-methyl-transferase gene polymorphism and drug-related toxicity in children treated for acute leukemia and Non-Hodgkins lymphomaEda Ataseven1, Buket Kosova2, Cagdas AKTAN3, Zafer Kurugöl4, Mehmet Kantar11Department of Pediatric Hematology and Oncology, Ege University Faculty of Medicine, Izmir, Turkey2Department of Medical Biology, Ege University Faculty of Medicine, Izmir, Turkey 3Department of Medical Biology, Beykent University Faculty of Medicine, Istanbul, Turkey 4Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey INTRODUCTION: Thiopurine S-methyltransferase (TPMT) is an essential enzyme in thiopurine drugs' metabolism, and its activity may be change due to different polymorphisms in the TPMT gene. TPMT gene has different genetic polymorphisms in different ethnic groups. This study aimed to determine the frequency of TPMT polymorphisms in children with acute leukemia/ non-Hodgkin lymphoma (AL/ NHL ) and healthy children and to evaluate their association with severe toxicities in the study population. Eda Ataseven, Buket Kosova, Cagdas AKTAN, Zafer Kurugöl, Mehmet Kantar. Thiopurine-S-methyl-transferase gene polymorphism and drug-related toxicity in children treated for acute leukemia and Non-Hodgkins lymphoma. . 2022; 9(1): 60-65 Corresponding Author: Eda Ataseven, Türkiye |
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