Ultrastructure of The Liver in Wilson’s Disease

Ultrastrustural changes in the liver parenchymal cells were observed in the liver biopsy specimen taken from a child patient suffering from Wilson's disease which was diagnosed on the basis of laboratory and clinical grounds. A variety of peculiar degenerative changes at the level of organelles, in particular, the mitochondria have been observed in the electron microscobical examination of liver tissue. In addition, the presence of lipofuscin granules have been described in the hepatocytes as a characteristic feature.