Antineoplastic Activity of Nickel (II)-Cystine Complex against Ehrlich Ascites Carcinoma in Swiss Albino Mice

Ni(II)-cystine complex was synthesized by treating saturated aqueous solutions of Ni (II) acetate and L(-) cystine (in 1: 1 molar ratio). The complex was used to study its antineoplastic activity against EAC cells in Swiss Albino mice. It was found that the Ni (II) complex restored the depleted haematological and biochemical parameters of the EAC bearing mice towards normal values and enhanced the longevity of such mice significantly. The test compound on the other hand showed negligible host toxicity. The results obtained were compared with those obtained with a standard anticancer drug bleomycin.