Study of MDA, Antioxidant Vitamins, Lipoproteins Serum Levels and Anthropometry Parameters in Coronary Artery Disease Patients

To compare the serum level of MDA (malondialdehyde), antioxidant vitamins, lipoproteins and anthropometry parameters, of 40 patients with coronary artery disease (CAD) and at least one vessel stenosis more than 70% and 40 healthy persons (control group) with mean age of 53.7±9.45 years were selected for this study. All patients and the healthy controls were evaluated in aspects of anthropometry parameters including weight, height, Basal Metabolic Index (BMI) and waist to hip ratio, angiographic status of coronary arteries (only in patient group), serum levels of triglyceride, cholesterol, LDL-C, HDL2, HDL3, MDA and vitamins E and C.
Results showed that BMI and waist to hip ratio in patients were significantly elevated in control group (p<0.01) whereas serum levels of antioxidant vitamins were lower (p<0.001). Serum levels of MDA in the patients were increased significantly in comparison with the control group (p<0.001). LDL/HDL ratios were higher and Vitamin E/Cholesterol ratios were lower of patients compared to the control group.
These results suggest that decrease of antioxidant vitamins and increase of MDA serum levels play important roles in the pathogenesis of CAD.