Histopathological Effects of The Residual Maneb and Zineb in The Lettuces on The Liver and Kidney of Albino Mice

Suspensions of carbamate fungicides (maneb and zineb) were prepared at the concentrations of 200 g maneb/100 L and 300 g zineb/100 L respectively. These two doses were applied to the albino mice by way of lettuces during 13 weeks. Three applications were done weekly. The histopathological effects of the fungicides on mice were investigated. The test animals were observed to have larger livers with more heavily color than those of the controls. Another observation was the fat accumulation around the internal organs, particularly on liver, kidneys and pancreas of the test animals. Histological examination of the liver and kidney has shown mononuclear cell infiltration, tissue necrosis and congestion in mice fed with fungicide-applied lettuces. The changes obtained from tissues were discussed.