Synthesis of Some New Heterocyclic Compounds with Expected Potential Biological Activity

Condensation of 4-acetylphenyl-3', 4'-xylene sulphonate with ethyl acetate in presence of sodium metal gave the 1,3-diketone (1). Reaction of 1 with hydrazine hydrate, phenyl hydrazine, hydroxylamine, o-aminophenol and thiourea has been studied. Condensation of 3,4-xylene sulphonate ester of p-hydroxy benzaldehyde VI with p-aminobenzoic acid gave the corresponding Schiff base VII. Reaction of VII with thioglycollic acid and chloroacetylchloride has been also studied.