Effect of Aprotinin on Joint Stiffness

Local aprotinin has been used during arthrotomy both expedimentally in the rats and clinically in the meniscectomy procedure.
Adhesion formation has been evaluated both histopathologically and clinically using the measurements of the Joints' range of motion.
In rats, adhesion rate was 66.66% in the control group, and 15.78 % in the aprotinin treated group P 0.05. Clinically, postoperative rehabilitation period was shorter in the aprotinin treated patients.
The results show that aprotinin significantly reduces the amount of adhesion formation but it does not effect collagen synthesis.