In vivo Antineoplastic Activities of Benzoin Thiosemicarbazone and Para-Anisaldehyde Semicarbazone against Ehrlich Ascites Carcinoma Cells

Two Schiff bases, namely benzoin thiosemicarbazone (BTSC) and para-anisaldehyde semicarbazone (PAS), were synthesized and characterized. The antineoplastic activities of these Schiff bases were studied against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice by monitoring tumor cell growth inhibition, tumor weight measurement, survival time of tumor-bearing mice, bioassay of these compounds, and counting the total number of peritoneal cells as well as macrophages. Hematological parameters were also studied. It was found that these compounds significantly reduced tumor cell growth rate, decreased tumor weight, and increased life span of EAC-bearing mice. These test compounds restored the hematological parameters of EAC-bearing mice to normal. These compounds also enhanced the number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin.