The Relation between Blood Cholesterol Levels and EEG Changes

Thirty three male albino rats, weighing 180-200 g were included in this experiment. Control animals consisting of 11 rats, were fed with a normal lab diet for a period of 12 weeks and the rest of the animals were fed with a diet containing 1% cholesterol for the same period. At the end of the experimental period, plasma cholesterol level (mean ± SD) was 134.04 ± 21.11 mg/dl in the cholesterol group and 72.72 ± 10.5 mg/dl in the control group. After feeding cholesterol group, eleven of the rats from the cholesterol group were transferred to the normal diet for 4 weeks (Normocholesterolemic group). The computerized spectral analysis of EEG records from parietal lobes of normal, hypercholesterolemic and normocholesterolemic rats by using the TRFC (Transient response-frequency characteristics) method showed that there was an obvious depression in the brain waves of hypercholesterolemic and normocholesterolemic animals.