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Comparative Study of Antineoplastic Activity of Some Aliphatic and Aromatic Hydroxamic Acids against Ehrlich Ascites Carcinoma (EAC) in MiceJ. A. Khanam1, S. P. Bag2, B. Sur2, P. Sur31From Department of Biochemistry, Rajshahi University, Bangladesh.2From Department of Chemistry, Jadavpur University, Calcutta, India. 3From Department of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta, India. Swiss mice inoculated with Ehrlich ascites carcinoma (EAC) cells were treated with chloroaceto-(CHA), aceto-(AHA), benzo-(BHA) and salicyl-(SHA) hydroxamic acids and also with clinically used anticancer agent hydroxyurea-(HU). Different biochemical (lipid peroxidation in serum, alkaline phosphatase activity) and haematological parameters as well as transplantability of treated EAC cells and enhanced peritoneal macrophages were studied. J. A. Khanam, S. P. Bag, B. Sur, P. Sur. Comparative Study of Antineoplastic Activity of Some Aliphatic and Aromatic Hydroxamic Acids against Ehrlich Ascites Carcinoma (EAC) in Mice. . 1998; 11(2): 57-64 Sorumlu Yazar: J. A. Khanam, Bangladesh |
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