Lipoprotein(A) as A Strong Risk Factor for Coronary Artery Disease in Iranian Population
Beman A. Jalali1, M. Rafie2, H. Mozaffari31Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.2Department of Cardiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.
3Department of Nutrition, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.
Lipoprotein(a) [Lp(a)] a cholesterol rich particle in human plasma, is a risk factor for coronary artery disease (CAD). The aim of present study was to determine and compare serum Lp(a) in the CAD patients with normal healthy volunteers in Iranian population.
This investigation included 117 patients (25 females, 92 males) with different degrees of coronary stenosis and 103 normal subjects (51 females, 52 males). Blood samples were collected in the morning after an overnight fasting and sera were stored at -20°C until the Lp(a) assay. The lipids and lipoproteins were measured by enzymatic methods and Lp(a) assay was done by electroimmunodiffusion.
The results showed that the serum Lp(a) did not correlate significantly with age, sex and other lipid risk factors. The Lp(a) levels in CAD group with a mean of 41±40 mg/dl were significantly higher than controls with a mean of 25.5±28 mg/dl (p<0.001).
We conclude that Lp(a) is an independent risk factor for atherosclerotic coronary artery disease in the Iranian population.
Sorumlu Yazar: Beman A. Jalali, Iran
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