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Influence of Concentration of Modified Maize Starch on Compaction Characteristics and Mechanical Properties of Paracetamol Tablet FormulationsMusibau A. Mustapha, Cecılıa I. Igwilo, Boladale O. SilvaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.Compact -forming ability of a multi-component paracetamol tablet formulations with varying amounts of modified Maize Starch incorporated as external disintegrant was studied with a view to know the influence of the increase on compaction characteristics and the quality of resulting tablets. Three formulations coded B-1, B-2 and B-3 with similar constituents but varying amount of modified Maize starch were designed and prepared by wet granulation process to yield granules that were compacted into tablets. Data and information were collected from out-of-die method; using hand operated tablet press at 5 predetermined pressures and fitted into Heckel plots. Compaction behaviours and mechanical properties of the tablets were evaluated. Musibau A. Mustapha, Cecılıa I. Igwilo, Boladale O. Silva. Influence of Concentration of Modified Maize Starch on Compaction Characteristics and Mechanical Properties of Paracetamol Tablet Formulations. . 2013; 21(3): 125-131 Sorumlu Yazar: Musibau A. Mustapha, Nigeria |
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