New Formulations from Acacia Nilotica L. and Glycyrrhiza Glabra L. for Oral Ulcer Remedy

This study addresses the innovation of a stable new pharmaceutical formulation comprising natural botanical extracts of Acacia nilotica L. and Glycyrrhiza glabra L., which are therapeutically effective in the treatment of oral ulcer and possess high patient acceptability.
The pastes are prepared, characterized, and subjected to physical and chemical stability studies and then evaluated for therapeutic efficacy regarding ulcer size.
The novel adhesive paste is prepared and when applied to the oral mucosa, it remains on it for a considerable period of time. The stability tests of all the samples in the analysis showed satisfactory physical and chemical stability evaluated by the Normal Stability Test. The mucoadhesive paste incorporating the active; A. nilotica L, when applied to oral ulcer, could promote the healing process, leading to a decrease in diameter of the inflammatory halo of the ulcer. However, the effect of liquorice extract on recurrent aphthous ulceration
(RAU) was found even better than that of acacia extract. A combination of the two plants presented a synergism of both, leading to better healing with favorable reduction of the diameter of inflammatory halo of the ulcer together with a prolonged action.
Therapeutically effective and stable oral pastes are dispensed with cost-effective benefits.