The Effect of Plasma Lipids on Gastric Mucosal Protection in Stress Ulcer

Besides the well known components of the gastric mucosal barrier, the role of gastric phospholipids in other words gastric surfactant is a new concept and yet it remains to be studied more. In this study, hypercholesterolemic rats which were subjected to restraining and cold stress were compared to their controls by means of gastric ulcer scores, mucosal phospholipid, cholesterol, total lipid and mucin contents. Since our results showed that the mucosae of hypercholesterolemic rats are more resistant to stress than those of controls we conclude that gastric mucosal lipids might be an important component of gastric mucosal barrier.