. 1999; 12(1): 13-24 | |||
Assessment of The Safety of Use of Certain Natural Anti-Inflammatory Agents and Their Effects on Nutritional Status in Adult and Growing RatsSahar Y. Al-Okbi1, Nagwa M. Ammar2, Doha A. Mohamed11Department of Food Sciences and Nutrition, National Research Centre, Dokki, Cairo, Egypt.2Department of Pharmaceutical Sciences, National Research Centre, Dokki, Cairo, Egypt. The objective of the present study is the determination of the safety of use of some natural agents proved previously to have a remarkable anti-inflammatory activity. So screening of certain biochemical and nutritional changes that may occur on administration of the natural anti-inflammatory agents and two reference anti-inflammatory drugs was carried out in both adult and growing rats. The natural agents undertaken in this study were the petroleum ether and the alcoholic extracts of fenugreek seeds and liquorice roots and the whole powder of coriander fruits (200 mg/kg). The reference drugs used are indomethacin and urbason retard (5 mg/kg). In the first experiment, the natural or synthetic anti-inflammatory agents were given as daily oral dose to different groups of normal adult rats for a month. At the end of the experiment the serum total protein, albumin, ALP, AST, ALT, creatinine, BUN, glucose, cholesterol, Ca, P, Fe and TIBC were determined. Nutritional parameters (such as food intake, body weight changes and food efficiency ratio) were assessed. The biochemical and nutritional parameters were compared with control rats given no medications. Results showed non-significant changes of any of the studied biochemical parameters after the administration of the natural agents. However urbason retard produced significant increase of serum albumin and ALT and significant decrease of serum globulin. Concerning nutritional parameters, petroleum ether extract of liquorice and urbason retard produced significant reduction of body weight gain and total food intake. Food efficiency ratios were reduced significantly on the administration of urbason retard. Sahar Y. Al-Okbi, Nagwa M. Ammar, Doha A. Mohamed. Assessment of The Safety of Use of Certain Natural Anti-Inflammatory Agents and Their Effects on Nutritional Status in Adult and Growing Rats. . 1999; 12(1): 13-24 Sorumlu Yazar: Sahar Y. Al-Okbi, Egypt |
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