Clinical Significance of Anticardiolipin Antibodies in Systemic Lupus Erythematosus
Sibel Ergüven1, Meral Calgüner2, A. Metin Gülmezoğlu3, Ekrem Gülmezoğlu1, Cem Sungur2, Osman Özcebe21From Hacettepe University, Department of Microbiology, Ankara, Turkiye.2From Hacettepe University, Department of Internal Medicine, Ankara, Turkiye.
3From Dr. Zekai Tahir Burak Women’s Hospital, Ankara,Türkiye.
We studied anticardiolipin antibody isotypes and VDRL in 45 systemic lupus erythematosus (SLE) patients. These patients were also screened for some other autoantibodies, such as anti-DNA, antimitochondrial (AMA) type 5 and antinuclear antibodies. Out of 45 patients, 55.5% were anticardiolipin (ACL) antibody positive. IgG class ACL antibodies were mainly detected in patients having thrombotic events and fetal losses. IgM class ACL antibody positivity was only associated with fetal losses. We also found a significant correlation between the presence of AMA type 5 and VDRL positivity with ACL-IgG and ACL-IgM antibodies.
Keywords: Anticardiolipin antibodies, fetal loss, antinuclear antibodies.Sibel Ergüven, Meral Calgüner, A. Metin Gülmezoğlu, Ekrem Gülmezoğlu, Cem Sungur, Osman Özcebe. Clinical Significance of Anticardiolipin Antibodies in Systemic Lupus Erythematosus. . 1989; 2(3): 189-192
Sorumlu Yazar: Sibel Ergüven, Türkiye
Sorumlu Yazar: Sibel Ergüven, Türkiye
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