Evaluation of clinical and laboratory prognostic risk factors in Organophosphate or carbamate-Poisoned Pediatric Patients

Objective: We aimed to determine the clinical and demographic features of pediatric patients monitored after organophosphorus or carbamate intoxication in our hospital. We further aimed to determine the clinical and laboratory indicators that may be effective on the clinical severity scores and the prognoses of the patients.
Methods: We retrospectively analyzed 117cases who were younger than18 years of age and were admitted to the pediatric emergency department for organophosphate or carbamate intoxication.
Results: The median age of the cases was 56 months (8–226 months) and the male/female ratio was 1.72 (74/43). The most frequent causes of intoxication were accidental ingestion (83.8%) and the most common cause and oral exposure as the most common route (73.5%). The Glasgow Coma Scale score and levels of pseudocholinesterase were significantly lower in the following groups: in the patient group with severe grade intoxication, in cases admitted to the intensive care unit, and in those with complications. However, lactate and glucose levels were significantly higher in those patient groups (p<0.001). The mean Red Distrubution Width levels were significantly higher in the patient group admitted to the intensive care unit compared with the group monitored in the emergency department (p= 0.029)
Conclusion: Our study helped us to conclude that the Glasgow Coma Scale score and serum Pseudocholinesterase, serum glucose, and serum lactate levels at baseline can be helpful in predicting the presence of a serious intoxication and aid in the prognosis in pediatric cases.