The diagnostic value of SCUBE1 in unstable angina pectoris patients

Aim
Signal peptide complement C1r/C1s, Uegf, and Bmp1 – epidermal growth factor – like domain- containing protein 1 (SCUBE1) has been used in research as a biomarker in acute coronary syndrome (ACS). The aim of this study is to determine if SCUBE1 and routine laboratory parameters are effective or not in distinguishing the patients presenting with clinical symptoms of unstable angina pectoris (USAP) from the patients who have non- ST-segment elevated myocardial infarction (NSTEMI) and non-cardiac chest pain patients (NCCP).

Material and Methods
The study group consisted of patients having chest pain or those suspected of having an ACS complaint. The study consisted of 5 groups of 185 patients with USAP, NSTEMI, STEMI, or NCCP and a control group of 45 healthy patients (CG). The study was conducted according to the American Heart Association (AHA) guidelines.

Results
There was no statistical difference between the patient groups and CG in terms of SCUBE1 (p=0.650). Troponin I value was significantly lower in USAP group than STEMI and NSTEMI groups (p < 0.001). There was no difference among the sub-groups of USAP in terms of the SCUBE1, GENSINI and the GRACE scores (p = 0.485, 0.932, 0.585).

Conclusion
SCUBE1 was not diagnostic for USAP, NSTEMI and STEMI. We need further studies to understand the value of SCUBE1 in ACS.