. 2023; 22(1): 0-0 | DOI: 10.4274/eajem.galenos.2021.57805  

Necrotizing Fasciitis as Complication use of Bevacizumab with Chemotherapy

Cantürk emir, Can Aktas, Alp Giray AYDIN
Department of Emergency Medicine, Koc University Hospital, İstanbul, Turkey

Necrotizing fasciitis is an uncommon, severe, life-threatening soft tissue infection involving the subcutaneous tissue. Immunocompromised and diabetic patients are at a higher risk of developing necrotizing fasciitis. One of the pathophysiologic mechanism of necrotizing fasciitis is subcutaneous arteries thrombosis and tissue ischemia. Bevacizumab, one of the agents used in cancer treatment, blocks the activity of vascular endothelial growth factor (VEGF) receptor. In recent years, it is used in combination with paclitaxel and carboplatin due to increase survival rate. The frequent use of this combination caused patients to apply to the emergency department with some side effects. Necrotizing fasciitis is one of the rare side effects of this combination. Here, we present a patient with ovarian cancer who was admitted to the emergency department with severe leg pain, whose initial examination and tests were normal, and then NF developed within hours and then arrested.

Keywords: Fasciitis, Necrotizing, Drug Therapy, Bevacizumab, Emergencies


Cantürk emir, Can Aktas, Alp Giray AYDIN. Necrotizing Fasciitis as Complication use of Bevacizumab with Chemotherapy. . 2023; 22(1): 0-0

Corresponding Author: Can Aktas, Türkiye


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