. 9999; 0: 0-0

Retrospective Analysis of Acute Pancreatitis Cases: Is Amylase or Lipase Alone Sufficient for the Diagnosis?

Gülşah Çıkrıkçı Işık, Resul Çinpolat, Yunsur Çevik
University of Health Sciences Kecioren Training and Research Hospital, Department of Emergency Medicine, Ankara, Turkey

Objectives: The aim of the study was to assess the diagnostic accuracy of the serum amylase and lipase in acute pancreatitis and perform a cost analysis of those enzymes to find out if one alone was sufficient for more cost-effective diagnostic process.
Methods: This was a retrospective study conducted in a hospital with a 335000 annual number of emergency department visits. All the patients to whom both amylase and lipase test were performed in 2019 were analyzed. Patients who had an elevation of three or more times the normal range of either amylase (> 300 U/L) or lipase (>195 U/L) were included into the study. Sensitivity of those enzymes in diagnosing acute pancreatitis were calculated. Cost measurement of amylase and lipase was determined.
Results: Number of patients with both enzyme levels measured for any reason at ED were 53944 in a year. 130 patients who met the including criteria were analyzed. 108 of the patients had raised levels of both enzymes. At 22 of those patients amylase was lower than the three fold of the normal range but lipase was significantly high. There were no patient with raised amylase with normal lipase levels. Sensitivity of serum amylase and lipase were 84% and %100 respectively. When lipase measured only for all patients whose amylase and lipase were measured, potential saving calculated as 71745 TL (10298 USD) annually.
Conclusion: “Lipase only” measurement is recommended in terms of diagnostic accuracy and cost effectiveness in the differential diagnosis of acute pancreatitis.

Keywords: Acute pancreatitis, amylase, lipase, cost, accuracy


Gülşah Çıkrıkçı Işık, Resul Çinpolat, Yunsur Çevik. Retrospective Analysis of Acute Pancreatitis Cases: Is Amylase or Lipase Alone Sufficient for the Diagnosis?. . 9999; 0: 0-0

Corresponding Author: Gülşah Çıkrıkçı Işık, Türkiye


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