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Concerning nephrotoxicity of Top Guns: Concomitant Piperacillin/Tazobactam and Vancomycin with Vancomycin alone during treatment of critically ill patientsSadaf Sheikh, Muhammad Akbar Baig, Muhammad Azhar Sharafat, Umair Javed, Umair JavedAga Khan University Hospital, Karachi, PakistanObjectives: Use of combination antibiotics piperacillin-tazobactam (PTZ) and Vancomycin (VAN) is so often used as ‘top guns’ for severe infections in hospitalized patients. VAN's nephrotoxicity is well-known. PTZ has been seen to prolong increased creatinine levels. Reports have surfaced in the literature of higher observed rates of acute kidney injury (AKI) among patients treated with combination of PTZ+VAN. The purpose of this study was to compare the prevalence of AKI with the use of VAN alone and combination of PTZ+VAN treatment at our institution. Our hypothesis was that the combination of PTZ+VAN will have higher prevalence of AKI as compared to VAN only. Sadaf Sheikh, Muhammad Akbar Baig, Muhammad Azhar Sharafat, Umair Javed, Umair Javed. Concerning nephrotoxicity of Top Guns: Concomitant Piperacillin/Tazobactam and Vancomycin with Vancomycin alone during treatment of critically ill patients. . 9999; 0: 0-0 Corresponding Author: Sadaf Sheikh, Pakistan |
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