The Effects of Amlodipine on Cerebral Circulatory Values in Patients With Essential Hypertension

Objective: This study assessed the effects of calcium chanelle blocker Amlodipine on the cerebral circulation in patientsz with essential hypertension. Methods: Cerebral circulation in 37 patients with essential hypertension and 10 healthy subjects was assessed using rheoplethysmography. In patients with essential hypertension cerebral circulation values were also re-estimated after treatment with Amlopidine (5-10 mg daily). Results: The cerebral circulatory parameters in hypertensive patients before treatment with Amlodipine were different from those in healthy persons. Amlodipine along with the reduction in systemic blood pressure caused attenuation of cerebrovascular abnormalities: decrease in spastic signs and incrase in cerebral blood supply in patients with essential hypertension. Conclusion: Amlodipine causes reduction of cerebral vascular resistance and promotes improvement in arterial blood filling in patients with essential hypertension. These changes in cerebral circulation may be secondary to the increase of cardiac output-known effect of Amlodipine.