Long noncoding RNA maternally expressed gene 3 (MEG3) rs4081134 gene polymorphism and preeclampsia risk

Objective: Preeclampsia (PE), a significant challenge for the health system, is a hypertensive disorder in pregnancy. Several studies have demonstrated the crucial role of long non-coding RNAs (lncRNAs) in the pathogenesis of preeclampsia (PE) by modulating maternal vascular smooth muscle cells and trophoblasts biological behaviors. This study was designed to assess the effect of MEG3 rs4081134 gene polymorphism on susceptibility to PE.
Materials and methods: We conducted a case-control study comprising 130 pregnant women with preeclampsia (PE) and 140 healthy pregnant women with normal pregnancies. The type of genotype was assigned using the PCR-RFLP method.
Results: There was a significant association between PE risk and AA genotype and the recessive model, suggesting that they may act as a protective factor in PE development. Other genotypes, genetic models, and Allelic distribution were not significantly related to the PE risk. Moreover, in pregnant women affected by preeclampsia, significant relationship was found between the newborn’s Birth weight and the MEG3 rs4081134 gene polymorphism.
Conclusion: We found a significant association between AA genotype, in addition to recessive model of MEG3 rs4081134 gene polymorphism and PE deployment. Furthermore, pertaining to women diagnosed with preeclampsia, there was a significant association between MEG3 rs4081134 gene polymorphism and newborn’s Birth weight.